larval mushroom body anterior paired lateral cell [FBbt_00110979]

larval mushroom body anterior paired lateral cell

ID: FBbt_00110979

GABAergic neuron of the larval mushroom body whose large cell body is located ventromedially. It extends one primary process dorsally that bifurcates at the level of the pedunculus, sending one secondary process to innervate the calyx and another one to the lobes. The calyx process branches into fine processes that terminate in boutons. The lobe secondary process runs along the lower pedunculus and terminates in fine branches in the terminal regions of the medial lobe, all regions of the vertical lobe and an area connecting the lower pedunculus and vertical lobe (spur/lower pedunculus). It also has postsynaptic terminals in the anterior superior medial protocerebrum. Pre-synaptic terminals are mainly found in the calyx, whereas dendrites are observed in the lobes. It synapses reciprocally with all (mature) Kenyon cells (Eichler et al., 2017). It develops from a neuroblast BLVa (Saumweber et al., 2018) and develops into the adult APL (Truman et al., 2023).

Pre-synaptic staining was achieved using the UAS-nSyb-GFP marker (FBal0118080) and postsynaptic staining using the UAS-DenMark (FBal0248657). GRASP experiments revealed widespread close contacts between the larval APL and Kenyon cells in the calyx and lobes. The presence of GABA was detected using a anti-GABA antibody (Masuda-Nakagawa et al., 2014). Classified as an MBIN and MBON in Saumweber et al., 2018. MBE12 synonym is from catmaid. Lineage given as BLVa3/4 in (Saumweber et al., 2018).