Tag: lineage_DM4_CM4

adult doublesex pC1 (female) neuron [FBbt_00047349]

Doublesex-expressing neuron of the female that is part of a cluster in the posterior medial region of the protocerebrum. There are 5 of these cells per hemisphere and they are derived from the DM4 neuroblast (Ren et al., 2016). They are generally more active in virgin females than mated females (Wang et al., 2020). Subclasses can be distinguished by their characteristic branching patterns (Wang et al., 2020). They are cholinergic (Wang et al., 2020).

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adult doublesex pC1a (female) neuron [FBbt_00049922]

Adult doublesex pC1 neuron of the female that, similar to pC1d and pC1e, has a contralateral projection that extends further laterally than that of pC1b and pC1c and lacks a characteristic branch into the dorsal ipsilateral superior lateral protocerebrum (Wang et al., 2020). Its contralateral branch crosses the midline at the level of the superior medial protocerebrum (Wang et al., 2020). Unlike pC1d and pC1e, it does not project ventromedially towards the esophageal foramen (Wang et al., 2020). It is strongly synapsed by and activated by sex peptide abdominal ganglion neurons (Wang et al., 2020).

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adult doublesex pC1b (female) neuron [FBbt_00049923]

Adult doublesex pC1 neuron of the female that, similar to pC1c, has a relatively short contralateral projection compared to pC1a, pC1d and pC1e and has a characteristic branch into the dorsal ipsilateral superior lateral protocerebrum (Wang et al., 2020). Its contralateral branch crosses the midline at the level of the superior medial protocerebrum, but unlike pC1c, it does not have a ventrally-directed branch on each side of this crossing point (Wang et al., 2020).

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adult doublesex pC1c (female) neuron [FBbt_00049924]

Adult doublesex pC1 neuron of the female that, similar to pC1b, has a relatively short contralateral projection compared to pC1a, pC1d and pC1e and has a characteristic branch into the dorsal ipsilateral superior lateral protocerebrum (Wang et al., 2020). Its contralateral branch crosses the midline at the level of the superior medial protocerebrum, but unlike pC1b, it has a ventrally-directed branch on each side of this crossing point (Wang et al., 2020).

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adult doublesex pC1d (female) neuron [FBbt_00049925]

Adult doublesex pC1 neuron of the female that, similar to pC1a and pC1e, has a contralateral projection that extends further laterally than that of pC1b and pC1c and lacks a characteristic branch into the dorsal ipsilateral superior lateral protocerebrum (Wang et al., 2020). Its contralateral branch crosses the midline at the level of the superior medial protocerebrum (Wang et al., 2020). Unlike pC1a, it projects ventromedially towards the esophageal foramen, with more extensive and more ventral arborization than pC1e (Wang et al., 2020). There is one of these cells per hemisphere and it is cholinergic (Schretter et al., 2020). It promotes female aggression (Schretter et al., 2020).

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adult doublesex pC1e (female) neuron [FBbt_00049926]

Adult doublesex pC1 neuron of the female that, similar to pC1a and pC1d, has a contralateral projection that extends further laterally than that of pC1b and pC1c and lacks a characteristic branch into the dorsal ipsilateral superior lateral protocerebrum (Wang et al., 2020). Its contralateral branch crosses the midline at the level of the superior medial protocerebrum (Wang et al., 2020). Unlike pC1a it projects ventromedially towards the esophageal foramen, but has less extensive arborization and does not extend as far ventrally as pC1d (Wang et al., 2020). There is one of these cells per hemisphere and it is cholinergic (Schretter et al., 2020).

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fru-P1 [FBbt_00110621]

Male-specific fruitless neuron with its soma in the dorsal posterior brain, mediolateral to the mushroom body (Kimura et al., 2008). It develops from the DM4 neuroblast (Ren et al., 2016). It extends a primary neurite anterodorsally, which ramifies extensively toward the lateral and medial protocerebrum regions (Kimura et al., 2008). A long prominent neurite crosses the midline through the anterior superior medial protocerebrum, ending at the corresponding contralateral region (Kimura et al., 2008). It has presynaptic sites in the protocerebral bridge (Duhart et al., 2020). These neurons are a subset of the doublesex pC1 neurons (Zhou et al., 2015). It is involved in the decision to initiate courtship song, including pulse and sine song (Philipsborn et al., 2011; O’Sullivan et al., 2018). Its activity can also suppress sleep (Duhart et al., 2020). It expresses the insulin receptor (InR) and is suppressed by insulin from the insulin producing cells of the pars intercerebralis (Zhang et al., 2022). There are approximately 50 of these cells per hemisphere (Ren et al., 2016).

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