3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity [GO_0010420]

Catalysis of the reaction: 3,4-dihydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-homocysteine + H+. Note that the polyprenyl sidechain substrate for this reaction has a different number of prenyl units in different organisms (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units.
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Open 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity in VFB

Term Information

  • ID: GO_0010420
  • Name: 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity
  • Definition: Catalysis of the reaction: 3,4-dihydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-homocysteine + H+.
  • Synonyms:
  • Type:
  • Comment: Note that the polyprenyl sidechain substrate for this reaction has a different number of prenyl units in different organisms (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units.

VFB Term Json

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    "term": {
        "core": {
            "iri": "http://purl.obolibrary.org/obo/GO_0010420",
            "symbol": "",
            "types": [
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            "short_form": "GO_0010420",
            "unique_facets": [
                "Class"
            ],
            "label": "3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity"
        },
        "description": [
            "Catalysis of the reaction: 3,4-dihydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-homocysteine + H+."
        ],
        "comment": [
            "Note that the polyprenyl sidechain substrate for this reaction has a different number of prenyl units in different organisms (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units."
        ]
    },
    "query": "Get JSON for Class",
    "version": "275438e",
    "parents": [
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/GO_0008757",
            "types": [
                "Entity",
                "Class",
                "has_subClass"
            ],
            "short_form": "GO_0008757",
            "unique_facets": [
                "Class"
            ],
            "label": "S-adenosylmethionine-dependent methyltransferase activity"
        }
    ],
    "relationships": [
        {
            "relation": {
                "iri": "http://purl.obolibrary.org/obo/BFO_0000050",
                "label": "is part of",
                "type": "part_of"
            },
            "object": {
                "symbol": "",
                "iri": "http://purl.obolibrary.org/obo/GO_0006744",
                "types": [
                    "Entity",
                    "Class"
                ],
                "short_form": "GO_0006744",
                "unique_facets": [
                    "Class"
                ],
                "label": "ubiquinone biosynthetic process"
            }
        }
    ],
    "xrefs": [],
    "anatomy_channel_image": [],
    "pub_syn": [
        {
            "synonym": {
                "scope": "has_related_synonym",
                "label": "polyprenyldihydroxybenzoate methyltransferase activity",
                "type": ""
            },
            "pub": {
                "core": {
                    "symbol": "",
                    "iri": "http://flybase.org/reports/Unattributed",
                    "types": [
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                    "short_form": "Unattributed",
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                "FlyBase": "",
                "PubMed": "",
                "DOI": ""
            }
        }
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    "def_pubs": []
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