neural crest [UBERON_0002342]

A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]. Gene notes: Many factors and genes, such as Pax3 (Tremblay et al., 1995), slug (Nieto et al., 1994), AP-2 (Zhang et al., 1996; Schorle et al., 1996), and Wnt-1/3a (Ikeya et al., 1997) are expressed in the dorsal most region of the neural tube, and have been shown to be involved in the generation of neural crest cells.
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Open neural crest in VFB

VFB Term Json

{
    "term": {
        "core": {
            "iri": "http://purl.obolibrary.org/obo/UBERON_0002342",
            "symbol": "",
            "types": [
                "Entity",
                "Anatomy",
                "Class"
            ],
            "short_form": "UBERON_0002342",
            "label": "neural crest"
        },
        "description": [
            "A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]."
        ],
        "comment": [
            "Gene notes: Many factors and genes, such as Pax3 (Tremblay et al., 1995), slug (Nieto et al., 1994), AP-2 (Zhang et al., 1996; Schorle et al., 1996), and Wnt-1/3a (Ikeya et al., 1997) are expressed in the dorsal most region of the neural tube, and have been shown to be involved in the generation of neural crest cells."
        ]
    },
    "query": "Get JSON for Class",
    "version": "44725ae",
    "parents": [
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/UBERON_0004121",
            "types": [
                "Entity",
                "Anatomy",
                "Class"
            ],
            "short_form": "UBERON_0004121",
            "label": "ectoderm-derived structure"
        },
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/UBERON_0010314",
            "types": [
                "Entity",
                "Anatomy",
                "Class"
            ],
            "short_form": "UBERON_0010314",
            "label": "structure with developmental contribution from neural crest"
        },
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/UBERON_0010316",
            "types": [
                "Entity",
                "Anatomy",
                "Class"
            ],
            "short_form": "UBERON_0010316",
            "label": "germ layer / neural crest"
        }
    ],
    "relationships": [
        {
            "relation": {
                "iri": "http://purl.obolibrary.org/obo/BFO_0000050",
                "label": "is part of",
                "type": "part_of"
            },
            "object": {
                "symbol": "",
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                "types": [
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                "short_form": "UBERON_0002346",
                "label": "neurectoderm"
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        },
        {
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                "label": "only in taxon",
                "type": "only_in_taxon"
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            "object": {
                "symbol": "",
                "iri": "http://purl.obolibrary.org/obo/NCBITaxon_89593",
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                "label": "Craniata <chordates>"
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            "relation": {
                "iri": "http://purl.obolibrary.org/obo/RO_0002488",
                "label": "existence starts during",
                "type": "existence_starts_during"
            },
            "object": {
                "symbol": "",
                "iri": "http://purl.obolibrary.org/obo/UBERON_0000110",
                "types": [
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                    "Class"
                ],
                "short_form": "UBERON_0000110",
                "label": "neurula stage"
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        },
        {
            "relation": {
                "iri": "http://purl.obolibrary.org/obo/RO_0002202",
                "label": "develops from",
                "type": "develops_from"
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            "object": {
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                ],
                "short_form": "UBERON_0003075",
                "label": "neural plate"
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        },
        {
            "relation": {
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                "type": "develops_from"
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            "object": {
                "symbol": "",
                "iri": "http://purl.obolibrary.org/obo/UBERON_0005062",
                "types": [
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                ],
                "short_form": "UBERON_0005062",
                "label": "neural fold"
            }
        },
        {
            "relation": {
                "iri": "http://purl.obolibrary.org/obo/RO_0002473",
                "label": "composed_primarily_of",
                "type": "composed_primarily_of"
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            "object": {
                "symbol": "",
                "iri": "http://purl.obolibrary.org/obo/CL_0000333",
                "types": [
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                ],
                "short_form": "CL_0000333",
                "label": "migratory neural crest cell"
            }
        }
    ],
    "xrefs": [],
    "anatomy_channel_image": [],
    "pub_syn": [
        {
            "synonym": {
                "scope": "has_related_synonym",
                "label": "crista neuralis",
                "type": "http://purl.obolibrary.org/obo/uberon/core#LATIN"
            },
            "pub": {
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                    "symbol": "",
                    "iri": "http://flybase.org/reports/Unattributed",
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                    "short_form": "Unattributed",
                    "label": ""
                },
                "FlyBase": "",
                "PubMed": "",
                "DOI": ""
            }
        }
    ],
    "def_pubs": []
}