endocardial cushion [UBERON_0002062]
The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA]. GO graph seems to suggest this is an endothelium. WP: The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial to mesenchymal transformation, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards to interior of the heart tube). Latest (2010-06-01) new def suggested for GO, added above. Note that EHDAA2 has a more detailed model which we may later adopt. JB: Patterning makes the cushions lay down connective tissue in three domains that force out the local endothelial lining and so the leaflets form
Note
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VFB Term Json
{
"term": {
"core": {
"iri": "http://purl.obolibrary.org/obo/UBERON_0002062",
"symbol": "",
"types": [
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"short_form": "UBERON_0002062",
"label": "endocardial cushion"
},
"description": [
"The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA]."
],
"comment": [
"GO graph seems to suggest this is an endothelium. WP: The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial to mesenchymal transformation, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards to interior of the heart tube). Latest (2010-06-01) new def suggested for GO, added above. Note that EHDAA2 has a more detailed model which we may later adopt. JB: Patterning makes the cushions lay down connective tissue in three domains that force out the local endothelial lining and so the leaflets form"
]
},
"query": "Get JSON for Class",
"version": "44725ae",
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{
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"types": [
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],
"short_form": "UBERON_0014387",
"label": "mesenchyme derived from neural crest"
},
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"label": "cardiac mesenchyme"
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{
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"types": [
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"short_form": "UBERON_0002050",
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"short_form": "UBERON_0005256",
"label": "trunk mesenchyme"
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"short_form": "UBERON_0002165",
"label": "endocardium"
}
}
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"xrefs": [],
"anatomy_channel_image": [],
"pub_syn": [
{
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"label": "AV cushion",
"type": ""
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{
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"type": "http://purl.obolibrary.org/obo/uberon/core#PLURAL"
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"short_form": "Unattributed",
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}
],
"def_pubs": []
}
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