VUM motor neuron [FBbt_00110181]
Motor neuron that is part of the median neuroblast lineage that innervates the larval body wall muscles. There are three of these cells per segment from T1 to A7. They are modulatory motor neurons; in A1-7, one VUM motor neuron innervates the dorsal muscles, one innervates the ventral muscles, and one innervates the lateral muscles. Neurotransmitter was assessed by the expression of the vesicular glutamate transporter (vGlut) (FBgn0031424) for glutamate; the enzyme that converts tyramine to octopamine, tyramine beta-hydroxylase (Tbh) (FBgn0010329) and the vesicular monoamine transporter gene (Vmat) (FBgn0260964) (Wheeler et al., 2006). Vomel and Wegener, 2008 used Tdc2-GAL4 (tyrosine decarboxylase - implies presence of tyramine) and anti-Tbh (implies presence of octopamine). Selcho et al., 2012 used Tdc2-GAL4, validated with anti-Tbh, anti-p-tyramine and anti-conjugated octopamine, to visualize tyraminergic and octopaminergic neurons. VUM neurons are found in thoracic and abdominal segments (Schmid et al., 1999).
Note
This page displays the raw VFB json record for this term. Please use the link below to open the term inside the Virtual Fly Brain viewerVFB Term Json
{
"term": {
"core": {
"iri": "http://purl.obolibrary.org/obo/FBbt_00110181",
"symbol": "",
"types": [
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"Cell",
"Class",
"Glutamatergic",
"Larva",
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"Neuron",
"Octopaminergic"
],
"short_form": "FBbt_00110181",
"label": "VUM motor neuron"
},
"description": [
"Motor neuron that is part of the median neuroblast lineage that innervates the larval body wall muscles. There are three of these cells per segment from T1 to A7. They are modulatory motor neurons; in A1-7, one VUM motor neuron innervates the dorsal muscles, one innervates the ventral muscles, and one innervates the lateral muscles."
],
"comment": [
"Neurotransmitter was assessed by the expression of the vesicular glutamate transporter (vGlut) (FBgn0031424) for glutamate; the enzyme that converts tyramine to octopamine, tyramine beta-hydroxylase (Tbh) (FBgn0010329) and the vesicular monoamine transporter gene (Vmat) (FBgn0260964) (Wheeler et al., 2006). Vomel and Wegener, 2008 used Tdc2-GAL4 (tyrosine decarboxylase - implies presence of tyramine) and anti-Tbh (implies presence of octopamine). Selcho et al., 2012 used Tdc2-GAL4, validated with anti-Tbh, anti-p-tyramine and anti-conjugated octopamine, to visualize tyraminergic and octopaminergic neurons. VUM neurons are found in thoracic and abdominal segments (Schmid et al., 1999)."
]
},
"query": "Get JSON for Class",
"version": "44725ae",
"parents": [
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/FBbt_00007681",
"types": [
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"short_form": "FBbt_00007681",
"label": "type II motor neuron"
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{
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"label": "larval glutamatergic neuron"
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"types": [
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"short_form": "FBbt_00058213",
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"short_form": "FBbt_00001592",
"label": "VUM neuron"
},
{
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"types": [
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"short_form": "FBbt_00058214",
"label": "larval tyraminergic neuron"
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{
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"types": [
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"short_form": "FBbt_00007675",
"label": "embryonic/larval motor neuron"
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],
"relationships": [
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"label": "synapsed_via_type_II_bouton_to",
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"object": {
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"iri": "http://purl.obolibrary.org/obo/FBbt_00000465",
"types": [
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"short_form": "FBbt_00000465",
"label": "embryonic/larval hypodermal muscle"
}
},
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0013009",
"label": "sends_synaptic_output_to_cell",
"type": "sends_synaptic_output_to_cell"
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"object": {
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"iri": "http://purl.obolibrary.org/obo/FBbt_00000465",
"types": [
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"Larva",
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],
"short_form": "FBbt_00000465",
"label": "embryonic/larval hypodermal muscle"
}
},
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0002100",
"label": "has soma location",
"type": "has_soma_location"
},
"object": {
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/FBbt_00111225",
"types": [
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"short_form": "FBbt_00111225",
"label": "cell body rind of larval ventral nerve cord"
}
}
],
"xrefs": [],
"anatomy_channel_image": [],
"pub_syn": [
{
"synonym": {
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"label": "ventral unpaired motorneuron",
"type": ""
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"symbol": "",
"iri": "http://flybase.org/reports/FBrf0072659",
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"label": "Bossing and Technau, 1994, Development 120(7): 1895--1906"
},
"FlyBase": "",
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"DOI": ""
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"label": "Vm",
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"iri": "http://flybase.org/reports/FBrf0180108",
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"label": "Kearney et al., 2004, Dev. Biol. 275(2): 473--492"
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"DOI": "10.1016/j.ydbio.2004.08.047"
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{
"synonym": {
"scope": "has_narrow_synonym",
"label": "vumTDC2",
"type": ""
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"iri": "http://flybase.org/reports/FBrf0210246",
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"label": "V\u00f6mel and Wegener, 2008, PLoS ONE 3(3): e1848"
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"PubMed": "18365004",
"DOI": "10.1371/journal.pone.0001848"
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},
{
"synonym": {
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"type": ""
},
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"label": ""
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},
{
"synonym": {
"scope": "has_exact_synonym",
"label": "mVUM",
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"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/FBrf0216654",
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"short_form": "FBrf0216654",
"label": "Zhang et al., 2011, PLoS ONE 6(10): e26197"
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"PubMed": "22046261",
"DOI": "10.1371/journal.pone.0026197"
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],
"def_pubs": [
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"iri": "http://flybase.org/reports/FBrf0208790",
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"short_form": "FBrf0208790",
"label": "Mauss et al., 2009, PLoS Biol. 7(9): e1000200"
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"FlyBase": "",
"PubMed": "19771146",
"DOI": "10.1371/journal.pbio.1000200"
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{
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"short_form": "FBrf0112030",
"label": "Schmid et al., 1999, Development 126(21): 4653--4689"
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"PubMed": "10518486",
"DOI": ""
},
{
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"short_form": "FBrf0072659",
"label": "Bossing and Technau, 1994, Development 120(7): 1895--1906"
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"FlyBase": "",
"PubMed": "7924995",
"DOI": ""
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{
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"short_form": "FBrf0180108",
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"FlyBase": "",
"PubMed": "15501232",
"DOI": "10.1016/j.ydbio.2004.08.047"
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]
}
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