glutathione oxidoreductase activity [GO_0097573]

Catalysis of the reaction: protein-S-S-glutathione + glutathione-SH = protein-SH + glutathione-S-S-glutathione. Note that this activity is different from GO:0015038 ‘glutathione disulfide oxidoreductase activity’. See PMID:18992757: “Grxs [glutaredoxins] can also reduce mixed disulfides between proteins or low molecular weight thiols and GSH in reactions that require only their N-terminal active- site cysteine. It is important to note that the reduction of glutathionylated substrates through the monothiol mechanism seems to be the major activity of Grxs; all dithiol Grxs described so far catalyze these reactions, but not all dithiol Grxs catalyze the reduction of protein disulfides by the dithiol mechanism”.
Tags:

Open glutathione oxidoreductase activity in VFB

VFB Term Json

{
    "term": {
        "core": {
            "iri": "http://purl.obolibrary.org/obo/GO_0097573",
            "symbol": "",
            "types": [
                "Entity",
                "Class"
            ],
            "short_form": "GO_0097573",
            "label": "glutathione oxidoreductase activity"
        },
        "description": [
            "Catalysis of the reaction: protein-S-S-glutathione + glutathione-SH = protein-SH + glutathione-S-S-glutathione."
        ],
        "comment": [
            "Note that this activity is different from GO:0015038 'glutathione disulfide oxidoreductase activity'. See PMID:18992757: \"Grxs [glutaredoxins] can also reduce mixed disulfides between proteins or low molecular weight thiols and GSH in reactions that require only their N-terminal active- site cysteine. It is important to note that the reduction of glutathionylated substrates through the monothiol mechanism seems to be the major activity of Grxs; all dithiol Grxs described so far catalyze these reactions, but not all dithiol Grxs catalyze the reduction of protein disulfides by the dithiol mechanism\"."
        ]
    },
    "query": "Get JSON for Class",
    "version": "44725ae",
    "parents": [
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/GO_0015035",
            "types": [
                "Entity",
                "Class"
            ],
            "short_form": "GO_0015035",
            "label": "MIA40:ERV1 (CHCHD4:GFER) oxidizes cysteine residues to cystine disulfide bonds"
        }
    ],
    "relationships": [],
    "xrefs": [],
    "anatomy_channel_image": [],
    "pub_syn": [],
    "def_pubs": [
        {
            "core": {
                "symbol": "",
                "iri": "http://flybase.org/reports/Unattributed",
                "types": [
                    "Entity",
                    "Individual",
                    "pub"
                ],
                "short_form": "Unattributed",
                "label": ""
            },
            "FlyBase": "",
            "PubMed": "",
            "DOI": ""
        }
    ]
}