Glc6P is isomerised to I3P by ISYNA1 in the cytosol [GO_0004512]
Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form.
Note
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VFB Term Json
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"short_form": "GO_0004512",
"label": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol"
},
"description": [
"Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form."
],
"comment": []
},
"query": "Get JSON for Class",
"version": "44725ae",
"parents": [
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"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0016872",
"types": [
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"short_form": "GO_0016872",
"label": "intramolecular lyase activity"
}
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"relationships": [],
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"anatomy_channel_image": [],
"pub_syn": [
{
"synonym": {
"scope": "has_related_synonym",
"label": "1L-myo-inositol-1-phosphate lyase (isomerizing)",
"type": ""
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"iri": "http://flybase.org/reports/Unattributed",
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