Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase [GO_0008534]
Catalysis of the removal of oxidized purine bases by cleaving the N-C1’ glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3’ of the apurinic (AP) site. Consider also annotating to the molecular function term ‘DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906’.
Note
This page displays the raw VFB json record for this term. Please use the link below to open the term inside the Virtual Fly Brain viewerOpen Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase in VFB
VFB Term Json
{
"term": {
"core": {
"iri": "http://purl.obolibrary.org/obo/GO_0008534",
"symbol": "",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0008534",
"label": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase"
},
"description": [
"Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site."
],
"comment": [
"Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'."
]
},
"query": "Get JSON for Class",
"version": "44725ae",
"parents": [
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0000702",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0000702",
"label": "oxidized base lesion DNA N-glycosylase activity"
}
],
"relationships": [],
"xrefs": [],
"anatomy_channel_image": [],
"pub_syn": [
{
"synonym": {
"scope": "has_broad_synonym",
"label": "bifunctional DNA glycosylase activity",
"type": ""
},
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"label": ""
},
"FlyBase": "",
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"DOI": ""
}
},
{
"synonym": {
"scope": "has_related_synonym",
"label": "formamidopyrimidine-DNA glycosylase activity",
"type": ""
},
"pub": {
"core": {
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],
"short_form": "Unattributed",
"label": ""
},
"FlyBase": "",
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}
},
{
"synonym": {
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"label": "DNA-formamidopyrimidine glycosylase activity",
"type": ""
},
"pub": {
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"short_form": "Unattributed",
"label": ""
},
"FlyBase": "",
"PubMed": "",
"DOI": ""
}
},
{
"synonym": {
"scope": "has_exact_synonym",
"label": "oxidized purine base lesion DNA N-glycosylase activity",
"type": ""
},
"pub": {
"core": {
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"iri": "http://flybase.org/reports/Unattributed",
"types": [
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],
"short_form": "Unattributed",
"label": ""
},
"FlyBase": "",
"PubMed": "",
"DOI": ""
}
},
{
"synonym": {
"scope": "has_broad_synonym",
"label": "DNA glycosylase/beta-lyase activity",
"type": ""
},
"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/Unattributed",
"types": [
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],
"short_form": "Unattributed",
"label": ""
},
"FlyBase": "",
"PubMed": "",
"DOI": ""
}
},
{
"synonym": {
"scope": "has_broad_synonym",
"label": "8-oxoguanine DNA glycosylase activity",
"type": ""
},
"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/Unattributed",
"types": [
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],
"short_form": "Unattributed",
"label": ""
},
"FlyBase": "",
"PubMed": "",
"DOI": ""
}
},
{
"synonym": {
"scope": "has_broad_synonym",
"label": "DNA glycosylase/AP-lyase activity",
"type": ""
},
"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/Unattributed",
"types": [
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"pub"
],
"short_form": "Unattributed",
"label": ""
},
"FlyBase": "",
"PubMed": "",
"DOI": ""
}
},
{
"synonym": {
"scope": "has_related_synonym",
"label": "purine-specific oxidized base lesion DNA N-glycosylase activity",
"type": ""
},
"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/Unattributed",
"types": [
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"pub"
],
"short_form": "Unattributed",
"label": ""
},
"FlyBase": "",
"PubMed": "",
"DOI": ""
}
}
],
"def_pubs": []
}
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