activation of cysteine-type endopeptidase activity involved in apoptotic process [GO_0006919]

Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process. This term should be used when the annotation refers to a process that occurs in a context of apoptotic cell death. To annotate gene products involved in activation of cysteine-type endopeptidases in other cellular process (e.g., cell cycle arrest) that do not necessarily develop into an apoptotic process, please use the more general parent term GO:0097202. Examples of ‘activation of cysteine-type endopeptidase activity involved in apoptotic process’ are cytochrome c and Apaf1. When cytochrome c is released from mitochondria and forms a complex with Apaf1, they form a scaffolding platform in which the pro-caspase 9 is bound (the ‘apoptosome’). The caspase is then cleaved and activated. Cytochrome c and Apaf1 are therefore involved in the conversion of the zymogen procaspase 9 to the active form of the caspase.
Tags:

Open activation of cysteine-type endopeptidase activity involved in apoptotic process in VFB

VFB Term Json

{
    "term": {
        "core": {
            "iri": "http://purl.obolibrary.org/obo/GO_0006919",
            "symbol": "",
            "types": [
                "Entity",
                "Class"
            ],
            "short_form": "GO_0006919",
            "label": "activation of cysteine-type endopeptidase activity involved in apoptotic process"
        },
        "description": [
            "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process."
        ],
        "comment": [
            "This term should be used when the annotation refers to a process that occurs in a context of apoptotic cell death. To annotate gene products involved in activation of cysteine-type endopeptidases in other cellular process (e.g., cell cycle arrest) that do not necessarily develop into an apoptotic process, please use the more general parent term GO:0097202. Examples of 'activation of cysteine-type endopeptidase activity involved in apoptotic process' are cytochrome c and Apaf1. When cytochrome c is released from mitochondria and forms a complex with Apaf1, they form a scaffolding platform in which the pro-caspase 9 is bound (the 'apoptosome'). The caspase is then cleaved and activated. Cytochrome c and Apaf1 are therefore involved in the conversion of the zymogen procaspase 9 to the active form of the caspase."
        ]
    },
    "query": "Get JSON for Class",
    "version": "44725ae",
    "parents": [
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/GO_0043280",
            "types": [
                "Entity",
                "Class"
            ],
            "short_form": "GO_0043280",
            "label": "positive regulation of cysteine-type endopeptidase activity involved in apoptotic process"
        }
    ],
    "relationships": [],
    "xrefs": [],
    "anatomy_channel_image": [],
    "pub_syn": [
        {
            "synonym": {
                "scope": "has_narrow_synonym",
                "label": "activation of metacaspase activity",
                "type": ""
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            "pub": {
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        {
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    "def_pubs": []
}