neuromuscular junction [GO_0031594]

The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. In vertebrates, the term ‘neuromuscular junction’ is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT.
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Open neuromuscular junction in VFB

VFB Term Json

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            "iri": "http://purl.obolibrary.org/obo/GO_0031594",
            "symbol": "",
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            "short_form": "GO_0031594",
            "label": "neuromuscular junction"
        },
        "description": [
            "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential."
        ],
        "comment": [
            "In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are  cholinergic and excitatory.  Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT."
        ]
    },
    "query": "Get JSON for Class",
    "version": "44725ae",
    "parents": [
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            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/GO_0045202",
            "types": [
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            "short_form": "GO_0045202",
            "label": "synapse"
        }
    ],
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                "short_form": "CL_0000100",
                "label": "motor neuron"
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                "short_form": "CL_0000187",
                "label": "muscle cell"
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    ],
    "xrefs": [],
    "anatomy_channel_image": [],
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        {
            "synonym": {
                "scope": "has_related_synonym",
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