Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking [GO_0003810]
Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
Note
This page displays the raw VFB json record for this term. Please use the link below to open the term inside the Virtual Fly Brain viewerOpen Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking in VFB
VFB Term Json
{
"term": {
"core": {
"iri": "http://purl.obolibrary.org/obo/GO_0003810",
"symbol": "",
"types": [
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],
"short_form": "GO_0003810",
"label": "Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking"
},
"description": [
"Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links."
],
"comment": []
},
"query": "Get JSON for Class",
"version": "44725ae",
"parents": [
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0016755",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0016755",
"label": "aminoacyltransferase activity"
}
],
"relationships": [],
"xrefs": [],
"anatomy_channel_image": [],
"pub_syn": [
{
"synonym": {
"scope": "has_exact_synonym",
"label": "transglutaminase activity",
"type": ""
},
"pub": {
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"iri": "http://flybase.org/reports/Unattributed",
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"label": ""
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},
{
"synonym": {
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"label": "fibrinoligase activity",
"type": ""
},
"pub": {
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"label": ""
},
"FlyBase": "",
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}
},
{
"synonym": {
"scope": "has_exact_synonym",
"label": "TGase activity",
"type": ""
},
"pub": {
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"short_form": "Unattributed",
"label": ""
},
"FlyBase": "",
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"DOI": ""
}
},
{
"synonym": {
"scope": "has_narrow_synonym",
"label": "tissue transglutaminase",
"type": ""
},
"pub": {
"core": {
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"iri": "http://flybase.org/reports/Unattributed",
"types": [
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"short_form": "Unattributed",
"label": ""
},
"FlyBase": "",
"PubMed": "",
"DOI": ""
}
}
],
"def_pubs": []
}
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