DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity [GO_0008657]

Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.

Open DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity in VFB

VFB Term Json

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            "iri": "http://purl.obolibrary.org/obo/GO_0008657",
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            "types": [
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            "short_form": "GO_0008657",
            "label": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity"
        },
        "description": [
            "Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2."
        ],
        "comment": []
    },
    "query": "Get JSON for Class",
    "version": "44725ae",
    "parents": [
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/GO_0004857",
            "types": [
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            "short_form": "GO_0004857",
            "label": "enzyme inhibitor activity"
        },
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/GO_0072586",
            "types": [
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                "Class"
            ],
            "short_form": "GO_0072586",
            "label": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity"
        }
    ],
    "relationships": [
        {
            "relation": {
                "iri": "http://purl.obolibrary.org/obo/RO_0002212",
                "label": "negatively regulates",
                "type": "negatively_regulates"
            },
            "object": {
                "symbol": "",
                "iri": "http://purl.obolibrary.org/obo/GO_0003918",
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                "short_form": "GO_0003918",
                "label": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"
            }
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    "anatomy_channel_image": [],
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            "FlyBase": "",
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            "DOI": ""
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