neuroblast NB5-4 [FBbt_00001416]

neuroblast NB5-4

ID: FBbt_00001416

Neuroblast that most frequently delaminates at S4 (Schmid et al., 1997). In the embryo, one of these cells can be found in each hemisegment from S3-A10 (Birkholz et al., 2013; Urbach et al., 2016. In the larva, it resumes proliferation in all thoracic segments (Lacin and Truman, 2016 and in the male abdominal 9 neuromere (Birkholz et al., 2013. The neurons that develop from this neuroblast after larval hatching form postembryonic lineage 22 (Lacin and Truman, 2016. (Urbach et al., 2016, Schmid et al., 1999, Schmidt et al., 1997, Birkholz et al., 2013, Lacin and Truman, 2016, Truman et al., 2004)

Using DiI with antibody labelling, Schmidt et al., 1997 propose NB5-4 produces 5-9 thoracic neurons or 3-4 abdominal motorneurons with ipsilateral targets. Schmid et al., 1999, also use DiI with en-GFP, but find 2-3 large cells that match descriptions of CCAP/CAP+ neurosecretory cells, along with abdomen-specific interneurons. Also, Schmid et al., 1999 state that NB5-4 delaminates during S5, whilst Schmidt et al., 1997 find that delamination occurs over the period of S3/4 to S5, most frequently at S4, and as such we have chosen to define NB5-4 as a stage 4 neuroblast.