histone H3K4 methyltransferase activity [GO_0042800]

Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of up to three methyl groups to the lysine residue at position 4 of the histone H3 protein.
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histone H3K4 methyltransferase activity

ID: GO_0042800

Class

Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of up to three methyl groups to the lysine residue at position 4 of the histone H3 protein.

Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.

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Classification

Alternative Names

Synonym Scope Reference
histone H3 lysine 4-specific methyltransferase activity exact synonym
histone methylase activity (H3-K4 specific) exact synonym mah
histone lysine N-methyltransferase activity (H3-K4 specific) exact synonym
histone H3K4 methylase activity exact synonym
histone-H3K4 methyltransferase activity exact synonym
histone methyltransferase activity (H3-K4 specific) exact synonym

References