guanyl-nucleotide exchange factor activity GO_0005085
guanyl-nucleotide exchange factor activity
ID: GO_0005085
Class
Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
Open in VFB 3D Browser →Classification
Relationships
- negatively regulates: GDP binding
- positively regulates: GTP binding
Alternative Names
| Synonym | Scope | Reference |
|---|---|---|
| Rab guanyl-nucleotide exchange factor activity | narrow synonym | |
| Ras guanyl-nucleotide exchange factor activity | narrow synonym | |
| cAMP-dependent guanyl-nucleotide exchange factor activity | narrow synonym | |
| ARF guanyl-nucleotide exchange factor activity | narrow synonym | |
| Ral guanyl-nucleotide exchange factor activity | narrow synonym | |
| Ran guanyl-nucleotide exchange factor activity | narrow synonym | |
| Rap guanyl-nucleotide exchange factor activity | narrow synonym | |
| Sar guanyl-nucleotide exchange factor activity | narrow synonym | |
| Rac guanyl-nucleotide exchange factor activity | narrow synonym | |
| GNRP | narrow synonym | |
| Rho guanyl-nucleotide exchange factor activity | narrow synonym | |
| Rho guanine nucleotide exchange factor | exact synonym | |
| GDS | exact synonym | |
| guanyl-nucleotide release factor activity | exact synonym | |
| GEF | exact synonym | |
| RhoGEF | exact synonym | |
| guanyl-nucleotide releasing factor | exact synonym | |
| GDP-dissociation stimulator activity | exact synonym |