Defective ABCC9 (in KCNJ11:ABCC9) does not transport K+ from extracellular region to cytosol [GO_0005242]
Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.
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"label": "Defective ABCC9 (in KCNJ11:ABCC9) does not transport K+ from extracellular region to cytosol"
},
"description": [
"Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself."
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"comment": []
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"query": "Get JSON for Class",
"version": "44725ae",
"parents": [
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"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0005249",
"types": [
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"short_form": "GO_0005249",
"label": "voltage-gated potassium channel activity"
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"iri": "http://purl.obolibrary.org/obo/GO_0099094",
"types": [
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"short_form": "GO_0099094",
"label": "ligand-gated cation channel activity"
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