oxidized purine nucleobase lesion DNA N-glycosylase activity GO_0008534
oxidized purine nucleobase lesion DNA N-glycosylase activity
ID: GO_0008534
Class
Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site.
Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'.
Open in VFB 3D Browser →Classification
Alternative Names
| Synonym | Scope | Reference |
|---|---|---|
| DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing] | related synonym | 3.2.2.23 |
| Fpg protein | related synonym | 3.2.2.23 |
| Fapy-DNA glycosylase activity | related synonym | 3.2.2.23 |
| 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity | related synonym | 3.2.2.23 |
| DNA-formamidopyrimidine glycosylase activity | related synonym | |
| formamidopyrimidine-DNA glycosylase activity | related synonym | |
| 2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity | related synonym | 3.2.2.23 |
| deoxyribonucleate glycosidase activity | related synonym | 3.2.2.23 |
| DNA glycosylase/beta-lyase activity | broad synonym | |
| bifunctional DNA glycosylase activity | broad synonym | |
| DNA glycosylase/AP-lyase activity | broad synonym | |
| 8-oxoguanine DNA glycosylase activity | broad synonym | |
| oxidized purine base lesion DNA N-glycosylase activity | exact synonym | |
| purine-specific oxidized base lesion DNA N-glycosylase activity | related synonym |