Virtual Fly Brain – lineage_NB7-3

Blog: embryonic GW neuron [FBbt_00001586]

Sat, 01 Jan 2022 00:00:00 +0000

embryonic GW neuron

ID: FBbt_00001586

lineage NB7-3 primary neuron

Embryonic motor neuron precursor that develops from the first ganglion mother cell in the 7-3 lineage (GMC 7-3a) (Higashijima et al., 1996; Isshiki et al., 2001) and is the Notch ON descendent of this GMC (Lee and Lundell, 2007). One of these cells is produced in each thoracic, abdominal (A1-A8) and labial hemisegment (Higashijima et al., 1996; Rogulja-Ortmann et al., 2007; Rickert et al., 2018). It only develops into a larval neuron in segments S3-T2, in more posterior segments it undergoes programmed cell death (Rogulja-Ortmann et al., 2007; Rickert et al., 2018).

According to Schmid et al. (1999) this motorneuron projects out of the posterior root of the ISN, joining the ISNd branch and innervates muscles VO4-6. However, this neuron was not identified by Landgraf et al. (1997). Found (and survives) in labial, but not maxillary or mandibular segments (Rickert et al., 2018 - FBrf0238045).

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## Classification

Relationships

develops from: ganglion mother cell GMC7-3a
is part of: presumptive embryonic/larval nervous system

Alternative Names

Synonym	Scope	Reference
embryonic 7-3M	exact synonym	Dittrich et al., 1997
embryonic 7-3M	exact synonym	Bossing et al., 1996

Blog: EW1 neuron [FBbt_00001583]

Sat, 01 Jan 2022 00:00:00 +0000

EW1 neuron

ID: FBbt_00001583

Larva Serotonergic lineage NB7-3 primary neuron

Serotonergic interneuron of embryonic/larval abdominal segments A1-A7. The axon bifurcates into two thick branches as it enters dorsally into the contralateral neuropil. These two primary branches initially diverge in opposite directions and grow along the medial two-thirds of the neuropil, forming a circular pattern, with the branches meeting at the dorsal end of the neuropil. These neurons also extend an ipsilateral neurite, that seems to fasciculate with the respective neurite of the serotonergic abdominal lateral neuron and follow a similar pathway, projecting anteriorly to form the majority of its branches in the next anterior segment. In the A7 abdominal segment, this neuron has a single primary neurite that extends centrally and forms extensive varicosities. It is born from the first-born ganglion mother cell of the 7-3 lineage (GMC 7-3a).

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## Classification

Relationships

develops_directly_from: ganglion mother cell GMC7-3a

Alternative Names

Synonym	Scope	Reference
larval serotonergic abdominal medial neuron	exact synonym	Chen and Condron, 2008

Blog: EW2 neuron [FBbt_00001584]

Sat, 01 Jan 2022 00:00:00 +0000

EW2 neuron

ID: FBbt_00001584

Larva Serotonergic lineage NB7-3 primary neuron

Serotonergic interneuron of embryonic/larval abdominal segments A1-A7. Its contralateral branch forms a complex pattern at the ventral border of the contralateral neuropil that extends along the lateral margins. Its ipsilateral branch seems to fasciculate with the respective neurite of the serotonergic abdominal medial neuron and follows a similar pathway, though extending a contralateral neurite about mid-level in the dorso-ventral and anterior-posterior axis. This neurite extends a short way anterior along a midline tract. It is born from the second-born ganglion mother cell of the 7-3 lineage (GMC 7-3b).

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## Classification

Relationships

develops_directly_from: ganglion mother cell GMC7-3b

Alternative Names

Synonym	Scope	Reference
larval serotonergic abdominal lateral neuron	exact synonym	Chen and Condron, 2008

Blog: EW3 neuron [FBbt_00001585]

Sat, 01 Jan 2022 00:00:00 +0000

EW3 neuron

ID: FBbt_00001585

Larva Peptidergic lineage NB7-3 primary neuron

Larval corozonergic interneuron that develops from the third GMC in the NB7-3 lineage (GMC 7-3c) (Novotny et al., 2002). There is one of these cells per hemisegment from T2 to A7 (Novotny et al., 2002).

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## Classification

Relationships

develops_directly_from: ganglion mother cell GMC7-3c

Alternative Names

Synonym	Scope	Reference
larval VNC corazonin neuron	exact synonym
larval VNC CRZ neuron	exact synonym

Blog: larval EW neuron [FBbt_00001582]

Sat, 01 Jan 2022 00:00:00 +0000

larval EW neuron

ID: FBbt_00001582

Larva lineage NB7-3 primary neuron

Larval interneuron that is derived from neuroblast NB7-3. These are the Notch OFF cells born from the three GMCs produced by NB7-3 (Lee and Lundell, 2007). They are all primary neurons, since NB7-3 does not generate a secondary lineage (Lacin and Truman, 2016). There are usually three of these per hemineuromere from S2-A8, but only two are found in each mandibular (S1) hemineuromere (Rickert et al., 2018). They project contralaterally (Higashijima et al., 1996; Rickert et al., 2018).

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## Classification

Relationships

bearer of: bilateral

Alternative Names

Synonym	Scope	Reference
lineage NB7-3 interneuron	exact synonym
7-3I	exact synonym