Blog: DPM [FBbt_00005780]

Sat, 01 Jan 2022 00:00:00 +0000

DPM

ID: FBbt_00005780

Adult GABAergic Serotonergic lineage DM3 DPMpm2 secondary neuron

A serotonergic (Lee et al., 2011) and GABAergic (Haynes et al., 2015) mushroom body intrinsic neuron of the adult whose large cell body (~12um) is located in the dorsal posterior medial area of the brain, ventromedial to the calyx (Waddell et al., 2000; Tanaka et al., 2008). There is one of these cells per hemisphere and it innervates the entire ipsilateral mushroom body lobe system and distal pedunculus (Tanaka et al., 2008; Li et al., 2020). Its cell body fiber bifurcates in the superior neuropils, with one branch entering the tip of the gamma lobe and the other branching to enter at the base of the alpha lobe/lateral gamma lobe and the tip of the alpha' lobe (Waddell et al., 2000; Tanaka et al., 2008). It is synapsed to and by Kenyon cells throughout the mushroom body lobes and also has outputs to dopaminergic mushroom body input neurons (DANs) and mushroom body output neurons (MBONs) (Takemura et al., 2017; Li et al., 2020). This neuron is also electrically connected to the mushroom body anterior paired lateral cell (Wu et al., 2011). It is involved in sleep and memory consolidation (Haynes et al., 2015). It is a secondary neuron (Truman et al., 2023) that develops from the DM3 neuroblast (Ito et al., 2013).

Pre-synaptic terminals were identified using the pre-synaptic marker Bruchpilot in DPM neurons genetically labelled with the c316-GAL4 driver (FBti0017056) (Pitman et al., 2011). Electrical connectivity was inferred using dye coupling (Wu et al., 2011). Neurotransmitter release was assessed by immunostaining to two different serotonergic antibodies: 5HT and Ddc (Lee et al., 2011). Detectable by its large amn-expressing cell body (Waddell et al., 2000).

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## Classification

Relationships

bearer of: unilateral
electrically_synapsed_to: adult mushroom body anterior paired lateral cell
expresses: amn
has synaptic IO in region: pedunculus of adult mushroom body, spur of adult mushroom body
is part of: adult brain
receives synaptic input from neuron: adult Kenyon cell
receives synaptic input in region: medial lobe of adult mushroom body, vertical lobe of adult mushroom body
sends synaptic output to cell: adult Kenyon cell, adult dopaminergic mushroom body input neuron, adult mushroom body output neuron
sends synaptic output to region: medial lobe of adult mushroom body, vertical lobe of adult mushroom body

Alternative Names

Synonym	Scope	Reference
DPM	exact synonym	Bates et al., 2025
DPM	exact synonym	Berg et al., 2025
MB-DPM	exact synonym	Tanaka et al., 2008
dorsal paired medial cell	exact synonym	Tanaka et al., 2008
DPM	exact synonym	Scheffer et al., 2020
DPM	exact synonym
DPM	exact synonym	Schlegel et al., 2024

Virtual Fly Brain – lineage_DM3_DPMpm2

Blog: DPM [FBbt_00005780]

DPM

Relationships

Alternative Names