U2_snRNA SO_0000392
U2_snRNA
ID: SO_0000392
Class
U2 is a small nuclear RNA (snRNA) component of the spliceosome (involved in pre-mRNA splicing). Complementary binding between U2 snRNA (in an area lying towards the 5' end but 3' to hairpin I) and the branchpoint sequence (BPS) of the intron results in the bulging out of an unpaired adenine, on the BPS, which initiates a nucleophilic attack at the intronic 5' splice site, thus starting the first of two transesterification reactions that mediate splicing.
Open in VFB 3D Browser →Classification
Alternative Names
| Synonym | Scope | Reference |
|---|---|---|
| small nuclear RNA U2 | exact synonym | CB |
| U2 snRNA | exact synonym | |
| snRNA U2 | exact synonym | CB |
| U2 small nuclear RNA | exact synonym | CB |