s-LNv Pdf neuron FBbt_00003764

s-LNv Pdf neuron

ID: FBbt_00003764

Adult s-LNv neuron that expresses Pdf (FBgn0023178). There are four of these in each ventral cluster of LNs. Short, fine fibers lacking presynaptic sites contact the accessory medulla, whilst longer processes project toward the dorsal protocerebrum and terminate dorsofrontal to the mushroom body calyx close to the pars lateralis and close to the DN2 neurons (Helfrich-Forster et al., 2007. Thes dorsal arbors contain both pre- and postsynaptic connections, including reciprocal connections to DN1p neurons (Yasuyama and Meinertzhagen, 2010, Fernandez et al., 2020, and their morphology and connectivity vary throughout the day (Gorostiza et al., 2014. Pdf rich dense-synaptic vesicles accumulate in terminal varicosities in these cells, but are not associated with presynaptic sites (Miskiewicz et al., 2004; Yasuyama and Meinertzhagen, 2010. They can be observed docked at the plasma membrane, suggesting paracrine release of Pdf. They drive the morning locomotor activity peak (Liang et al., 2016; Liang et al., 2017; Delventhal et al., 2019 and display a morning neural activity peak that precedes this increased locomotor activity (Liang et al., 2016. (Helfrich-Forster et al., 2007, Hermann-Luibl et al., 2014, Gorostiza et al., 2014, Yasuyama and Meinertzhagen, 2010, Rieger et al., 2006, Miskiewicz et al., 2004, Liang et al., 2017, Delventhal et al., 2019, Fernandez et al., 2020, Liang et al., 2016)

Dorsal projections judged by curator to terminate in the superior lateral protocerebrum (SLP) as defined by the Ito et al. (2014) standard. This is the only group of pacemaker neurons currently classed as 'morning cells' (Liang et al., 2016; Liang et al., 2017; Delventhal et al., 2019. In some older papers, it is unclear whether l-LNvs are included as 'morning cells' (Grima et al., 2004 - FBrf0179741; Lear et al., 2009 - FBrf0208444).