LC4 FBbt_00003874
LC4
ID: FBbt_00003874
Lobula columnar neuron whose cell body is in an extended region of the lateral cell body rind (Wu et al., 2016. It has its main dendritic arbors in lobula layers 2 and 4 (Wu et al., 2016; Tanaka and Clark, 2022. Its arbors span approximately 40 optic columns, overlapping with other LC4 cells (Wu et al., 2016. It projects to an optic glomerulus in the PVLP that is medial to the one from LC12 and ventral to LPLC2 and LPLC1 (Wu et al., 2016. There are an estimated 66 neurons of this type (Wu et al., 2016. It has been reported as being both glutamatergic (Raghu and Borst, 2011 and cholinergic (Davis et al., 2020. (Fischbach and Dittrich, 1989, Otsuna and Ito, 2006, Davis et al., 2020, Wu et al., 2016, Tanaka and Clark, 2022, Raghu and Borst, 2011)
The glutamate neurotransmitter was assessed by labelling cells with a vGlut[CNSIII]-GAL4 driver (FBti0129148) (Raghu and Borst, 2011. The acetylcholine neurotransmitter was assessed by scRNAseq detection of choline acetyltransferase (FBgn0000303) and vesicular acetylcholine transporter (FBgn0270928) expression (Davis et al., 2020. Otsuna states that lcn4 innervates an optic glomerulus in the vlpr and vlpr maps to the VLP in Ito et al. (2014). Pre- versus postsynaptic innervation judged by scoring of terminal morphology from figures in Fischbach and Dittrich, 1989 as assessed by FlyBrain Neuron DB and with a presynaptic marker (synaptotagmin-HA driver) (Wu et al., 2016.
Open in VFB 3D Browser →Classification
- adult cholinergic neuron
- adult glutamatergic neuron
- lobula columnar neuron
- optic lobe wide-field columnar neuron
Relationships
- capable_of_part_of: visual behavior (PMID:30827912, PMID:35290791, PMID:31182867)
- capable_of_part_of: flight behavior (PMID:30827912, PMID:35290791, PMID:31182867)
- has soma location: adult lateral brain cell body rind
- receives synaptic input in region: lobula layer 2, lobula layer 4
- sends synaptic output to region: LC4 optic glomerulus
Alternative Names
| Synonym | Scope | Reference |
|---|---|---|
| LC4 | related synonym | Berg et al., 2025, Bates et al., 2025, Nern et al., 2025, name_in_male-cns, Scheffer et al., 2020, Schlegel et al., 2024 |
| lobular columnar neuron Lcn4 | exact synonym | |
| lobula columnar neuron Lcn4 | exact synonym | Fischbach and Dittrich, 1989 |
| ColA | exact synonym | Mu et al., 2012 |
| LC04 | exact synonym | Panser et al., 2016 |
Cross References
- LC4 on FlyBrain NeuronDB (10001)
Downloads
Image files aligned to VGlut-F-100043:
Image files aligned to Gad1-F-800054:
Image files aligned to VGlut-F-700288:
Image files aligned to VGlut-F-900042:
Image files aligned to LC4:
Image files aligned to BANC_626:720575941558515501:
Image files aligned to VGlut-F-100043:
Image files aligned to Gad1-F-800054:
Image files aligned to VGlut-F-700288:
Image files aligned to VGlut-F-900042: