larval insulin secreting cell of pars intercerebralis [FBbt_00110035]
Insulin-producing neurosecretory cell of the larval pars intercerebralis. Its axonal projection bifurcates, with one of the main branches projecting to the contralateral side and exiting the brain and bifurcating again. One of these secondary branches fasciculates with the nerve tracts that innervate the corpus cardiacum in the ring gland and also innervates the hypocerebral ganglion. The other follows the aorta and innervates the heart (Cao and Brown, 2001, Rulifson et al., 2002, Ikeya et al., 2002). The other main projection innervates the subesophageal ganglion, the esophagus (Rulifson et al., Ikeya et al., 2002) and the tritocerebrum (de Velasco et al., 2007). In third instar larva, the axonal processes project contralaterally and posteriorly, make a U-turn and extend anteriorly to terminals outside the brain. The dendritic processes extend ventrally and laterally (Cao et al., 2014). There are seven of these cells in each hemisphere (Cao and Brown, 2001, Rulifson et al., 2002, Ikeya et al., 2002, Cao et al., 2014). The same cells express Ilp2, Ilp3 and Ilp5 mRNA with different temporal profiles (Ikeya et al., 2002). These cells also express dimmed (FBgn0023091) and Drosulfakinin (FBgn0000500) (Park et al., 2008). They receive synaptic input from hugin neurons of the protocerebrum (Schlegel et al., 2016). These cells were identified in second and third instar larva (Ikeya et al., 2002). Insulin-producing cells are found amongst the median neurosecretory cells, but not all mNSCs are IPCs (FlyBase:FBrf0212696), despite misleading phrasing in some articles (e.g. FlyBase:FBrf0184236). Synapsing identified in full L1 VNC EM volume - all insulin cells have connections from multiple hugin-PC cells (Schlegel et al., 2016).
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VFB Term Json
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"label": "Schlegel et al., 2016, eLife 5: e16799"
},
"FlyBase": "FBrf0234450",
"PubMed": "27845623",
"DOI": "10.7554/eLife.16799"
}
]
}
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