KCab [FBbt_00100248]

KCab

ID: FBbt_00100248

Mushroom body neuron that bifurcates at the anterior end of the pedunculus and projects into the alpha and beta lobes of the adult mushroom body (Lee et al., 1999). The alpha/beta neurons are the last born of the Kenyon cells, generated during the pupal stage (Lee et al., 1999). In the pedunculus, the alpha/beta neurons occupy the core stratum with the alpha'/beta' neurons in the intermediate stratum and the gamma neurons at the periphery (Tanaka et al., 2008; Li et al., 2020). They are cholinergic neurons (Pankova & Borst, 2017) and they express sNPF (Johard et al., 2008; Barnstedt et al., 2016; Croset et al., 2018). There are around 900-1000 of these cells per hemisphere (Aso et al., 2014; Li et al., 2020).

Neuron was assessed to be cholinergic by Pankova & Borst (2017), based on anti-HA antibody detection of HA-tagged VAChT expression; Barnstedt et al. (2016) show that Kenyon cells express ChAT and VAChT proteins, and that antagonism of nicotinic ACh receptors or reduction of ACh processing in Kenyon cells impairs Kenyon cell-evoked responses in mushroom body output neurons.