histone H4K16 deacetylase activity, NAD-dependent [GO_0046970]
Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + NAD+ + H2O = histone H4 L-lysine (position 16) + 2’’-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group attached to a lysine residue in H4K16 to NAD, producing nicotinamide.
histone H4K16 deacetylase activity, NAD-dependent
ID: GO_0046970
Class
Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + NAD+ + H2O = histone H4 L-lysine (position 16) + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group attached to a lysine residue in H4K16 to NAD, producing nicotinamide.
Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
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Alternative Names
| Synonym | Scope | Reference |
|---|---|---|
| NAD-dependent histone H4-K16 deacetylase activity | exact synonym | |
| NAD-dependent histone H4K16 deacetylase activity | exact synonym | |
| NAD-dependent histone deacetylase activity (H4-K16 specific) | exact synonym |
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