histone H4K16 deacetylase activity, hydrolytic mechanism [GO_0034739]

Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein.
Tags:

histone H4K16 deacetylase activity, hydrolytic mechanism

ID: GO_0034739

Class

Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein.

Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.

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Classification

Alternative Names

Synonym Scope Reference
histone H4K12 deacetylase activity broad synonym
histone H4-K16 deacetylase activity exact synonym
histone deacetylase activity (H4-K16 specific) exact synonym