histone H4K12 deacetylase activity, hydrolytic mechanism [GO_0140937]
Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 12) + H2O = histone H4 L-lysine (position 12) + acetate. This reaction represents the removal of an acetyl group from lysine at position 12 of the histone H4 protein.
histone H4K12 deacetylase activity, hydrolytic mechanism
ID: GO_0140937
Class
Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 12) + H2O = histone H4 L-lysine (position 12) + acetate. This reaction represents the removal of an acetyl group from lysine at position 12 of the histone H4 protein.
Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
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Alternative Names
| Synonym | Scope | Reference |
|---|---|---|
| histone H4K12 deacetylation | related synonym | |
| histone H4K12 deacetylase activity | broad synonym | |
| histone H4-K12 deacetylase activity | exact synonym | |
| histone deacetylase activity (H4-K12 specific) | exact synonym | |
| histone H4-K12 deacetylation | related synonym |
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