embryonic immature Va neurosecretory neuron [FBbt_00053351]

embryonic immature Va neurosecretory neuron

ID: FBbt_00053351

Immature neuron in the developing VNC of the embryo that is derived from neuroblast NB5-3 and has a ventral soma (Suska et al., 2011; Gabilondo et al., 2011; Gabilondo et al., 2018. It is a Notch OFF neuron and its sibling Notch on cell dies by apoptosis (Gabilondo et al., 2011. In segments A1-A4, these cells develop into neurosecretory cells (Suska et al., 2011; Gabilondo et al., 2018. More posterior neurons undergo apoptosis prior to stage 16 (Suska et al., 2011; Gabilondo et al., 2011. In thoracic segments, they do not acquire a neurosecretory fate (Suska et al., 2011. (Gabilondo et al., 2018, Suska et al., 2011, Gabilondo et al., 2011)

Gabilondo et al., 2011 only show Capa+ A2-A7 neurons. Gabilondo et al., 2018 additionally show A1 Va neuron in NB5-3 lineage. Suska et al., 2011 show Dac+/Dimm+ cells in A8 and Dimm+ in T1-3 in same position as Va and refer to these as 'Va'. They do not directly demonstrate developmental origin, but A8 neurons survive and produce Capa in Abd-B mutants, suggesting Va identity. Gabilondo et al., 2018 could transform thoracic neurons into AstA+/Dh31+ cells with Ubx expression, also suggesting Va identity.