DNp45 [FBbt_20011346]

Adult descending neuron with its soma in the brain, posterior to the posterior lateral protocerebrum (Schlegel et al., 2024; Dorkenwald et al., 2024). It is a putative embryonic-born neuron (Schlegel et al., 2024; Dorkenwald et al., 2024). In the brain, it has postsynapses in the ipsilateral anterior ventrolateral protocerebrum and inferior clamp, and presynapses in the gnathal ganglion, the saddle and the ipsilateral flange (Schlegel et al., 2024; Dorkenwald et al., 2024). Within the VNC, it fasciculates with the ventral median tract of ventral cervical fasciculus and sends output to the leg neuropil and lower tectulum (Takemura et al., 2024; Marin et al., 2024). Its predicted neurotransmitter is acetylcholine (Eckstein et al., 2024). There are approximately 2 of these cells per organism (Schlegel et al., 2024; Dorkenwald et al., 2024; Sturner et al., 2025).
DNp45 DNp45

DNp45

ID: FBbt_20011346

Adult Cholinergic Nervous system primary neuron

Adult descending neuron with its soma in the brain, posterior to the posterior lateral protocerebrum (Schlegel et al., 2024; Dorkenwald et al., 2024). It is a putative embryonic-born neuron (Schlegel et al., 2024; Dorkenwald et al., 2024). In the brain, it has postsynapses in the ipsilateral anterior ventrolateral protocerebrum and inferior clamp, and presynapses in the gnathal ganglion, the saddle and the ipsilateral flange (Schlegel et al., 2024; Dorkenwald et al., 2024). Within the VNC, it fasciculates with the ventral median tract of ventral cervical fasciculus and sends output to the leg neuropil and lower tectulum (Takemura et al., 2024; Marin et al., 2024). Its predicted neurotransmitter is acetylcholine (Eckstein et al., 2024). There are approximately 2 of these cells per organism (Schlegel et al., 2024; Dorkenwald et al., 2024; Sturner et al., 2025).

Type identified at light level and matched across EM datasets by Sturner et al. (2025). Pre- or post-synapse locations are those with the highest total count of these neurons in FlyWire FAFB.

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## Classification

Relationships

Alternative Names

Synonym Scope Reference
DNxn078 exact synonym Stürner et al., 2025
DNp45 exact synonym doi_10_1101_2023_06_05_543407
DNp45 exact synonym doi_10_7554_eLife_97766_1
DNp45 exact synonym

List all available images of DNp45 (2 total)

Thumbnail Name Tags
TBD (MANC:16842) Nervous_system, primary_neuron, Adult, Cholinergic
TBD (MANC:16842) Nervous_system, primary_neuron, Adult, Cholinergic
TBD (MANC:17575) Nervous_system, primary_neuron, Adult, Cholinergic
TBD (MANC:17575) Nervous_system, primary_neuron, Adult, Cholinergic
TBD (MANC:17575) Nervous_system, primary_neuron, Adult, Cholinergic

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Downstream connectivity classes for DNp45 (210 total)

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Upstream connectivity classes for DNp45 (75 total)

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