DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO_0003918]
Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.
Note
This page displays the raw VFB json record for this term. Please use the link below to open the term inside the Virtual Fly Brain viewerOpen DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity in VFB
VFB Term Json
{
"term": {
"core": {
"iri": "http://purl.obolibrary.org/obo/GO_0003918",
"symbol": "",
"types": [
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],
"short_form": "GO_0003918",
"label": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"
},
"description": [
"Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2."
],
"comment": []
},
"query": "Get JSON for Class",
"version": "44725ae",
"parents": [
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0008094",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0008094",
"label": "ATP-dependent activity, acting on DNA"
},
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0003916",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0003916",
"label": "DNA topoisomerase activity"
}
],
"relationships": [],
"xrefs": [],
"anatomy_channel_image": [],
"pub_syn": [
{
"synonym": {
"scope": "has_narrow_synonym",
"label": "topoisomerase II",
"type": ""
},
"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/Unattributed",
"types": [
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"pub"
],
"short_form": "Unattributed",
"label": ""
},
"FlyBase": "",
"PubMed": "",
"DOI": ""
}
}
],
"def_pubs": []
}
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