DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity [GO_0072587]
Binds to and increases the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
Note
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VFB Term Json
{
"term": {
"core": {
"iri": "http://purl.obolibrary.org/obo/GO_0072587",
"symbol": "",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0072587",
"label": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity"
},
"description": [
"Binds to and increases the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2."
],
"comment": []
},
"query": "Get JSON for Class",
"version": "44725ae",
"parents": [
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0008047",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0008047",
"label": "enzyme activator activity"
},
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0072586",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0072586",
"label": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity"
}
],
"relationships": [
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0002213",
"label": "positively regulates",
"type": "positively_regulates"
},
"object": {
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0003918",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0003918",
"label": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"
}
}
],
"xrefs": [],
"anatomy_channel_image": [],
"pub_syn": [],
"def_pubs": [
{
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/Unattributed",
"types": [
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"Individual",
"pub"
],
"short_form": "Unattributed",
"label": ""
},
"FlyBase": "",
"PubMed": "",
"DOI": ""
}
]
}
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