class II DNA-(apurinic or apyrimidinic site) endonuclease activity [GO_0052720]

Catalysis of the hydrolysis of ester linkages immediately 5’ to an apurinic/apyrimidinic (AP; also called abasic) site within a deoxyribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5’-deoxyribose phosphate and 3’-hydroxyl ends. Class II AP endonuclease is a nuclease, but not Class I, III and IV.
Tags:

Open class II DNA-(apurinic or apyrimidinic site) endonuclease activity in VFB

VFB Term Json

{
    "term": {
        "core": {
            "iri": "http://purl.obolibrary.org/obo/GO_0052720",
            "symbol": "",
            "types": [
                "Entity",
                "Class"
            ],
            "short_form": "GO_0052720",
            "label": "class II DNA-(apurinic or apyrimidinic site) endonuclease activity"
        },
        "description": [
            "Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a deoxyribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends."
        ],
        "comment": [
            "Class II AP endonuclease is a nuclease, but not Class I, III and IV."
        ]
    },
    "query": "Get JSON for Class",
    "version": "44725ae",
    "parents": [
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/GO_0003906",
            "types": [
                "Entity",
                "Class"
            ],
            "short_form": "GO_0003906",
            "label": "NEIL1,NEIL2 incises DNA strand 5' to the AP site"
        },
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/GO_0016888",
            "types": [
                "Entity",
                "Class"
            ],
            "short_form": "GO_0016888",
            "label": "SPO11 hydrolyzes DNA forming double-strand breaks"
        }
    ],
    "relationships": [],
    "xrefs": [],
    "anatomy_channel_image": [],
    "pub_syn": [
        {
            "synonym": {
                "scope": "has_exact_synonym",
                "label": "class II DNA-(apurinic or apyrimidinic site) lyase activity",
                "type": ""
            },
            "pub": {
                "core": {
                    "symbol": "",
                    "iri": "http://flybase.org/reports/Unattributed",
                    "types": [
                        "Entity",
                        "Individual",
                        "pub"
                    ],
                    "short_form": "Unattributed",
                    "label": ""
                },
                "FlyBase": "",
                "PubMed": "",
                "DOI": ""
            }
        }
    ],
    "def_pubs": [
        {
            "core": {
                "symbol": "",
                "iri": "http://flybase.org/reports/Unattributed",
                "types": [
                    "Entity",
                    "Individual",
                    "pub"
                ],
                "short_form": "Unattributed",
                "label": ""
            },
            "FlyBase": "",
            "PubMed": "",
            "DOI": ""
        }
    ]
}