class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO_0140078]
Catalysis of the cleavage of an AP site 3’ of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3’-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5’-phosphate. Note that this term is does not have parentage in the ’nuclease activity’ branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. Class II AP endonuclease is a nuclease, but not Class I, III and IV.
Note
This page displays the raw VFB json record for this term. Please use the link below to open the term inside the Virtual Fly Brain viewerOpen class I DNA-(apurinic or apyrimidinic site) endonuclease activity in VFB
VFB Term Json
{
"term": {
"core": {
"iri": "http://purl.obolibrary.org/obo/GO_0140078",
"symbol": "",
"types": [
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],
"short_form": "GO_0140078",
"label": "class I DNA-(apurinic or apyrimidinic site) endonuclease activity"
},
"description": [
"Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate."
],
"comment": [
"Note that this term is does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. Class II AP endonuclease is a nuclease, but not Class I, III and IV."
]
},
"query": "Get JSON for Class",
"version": "44725ae",
"parents": [
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0003906",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0003906",
"label": "NEIL1,NEIL2 incises DNA strand 5' to the AP site"
},
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0016835",
"types": [
"Entity",
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],
"short_form": "GO_0016835",
"label": "carbon-oxygen lyase activity"
}
],
"relationships": [],
"xrefs": [],
"anatomy_channel_image": [],
"pub_syn": [
{
"synonym": {
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"label": "class I DNA-(apurinic or apyrimidinic site) lyase activity",
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},
{
"synonym": {
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"label": "DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity",
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},
{
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},
"FlyBase": "",
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}
},
{
"synonym": {
"scope": "has_exact_synonym",
"label": "AP site-DNA 5'-phosphomonoester-lyase activity",
"type": ""
},
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"label": ""
},
"FlyBase": "",
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}
},
{
"synonym": {
"scope": "has_related_synonym",
"label": "AP endonuclease class I activity",
"type": ""
},
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},
"FlyBase": "",
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}
}
],
"def_pubs": []
}
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