class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO_0140078]

Catalysis of the cleavage of an AP site 3’ of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3’-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5’-phosphate. Note that this term is does not have parentage in the ’nuclease activity’ branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. Class II AP endonuclease is a nuclease, but not Class I, III and IV.

Open class I DNA-(apurinic or apyrimidinic site) endonuclease activity in VFB

VFB Term Json

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            "iri": "http://purl.obolibrary.org/obo/GO_0140078",
            "symbol": "",
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            ],
            "short_form": "GO_0140078",
            "label": "class I DNA-(apurinic or apyrimidinic site) endonuclease activity"
        },
        "description": [
            "Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate."
        ],
        "comment": [
            "Note that this term is does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. Class II AP endonuclease is a nuclease, but not Class I, III and IV."
        ]
    },
    "query": "Get JSON for Class",
    "version": "44725ae",
    "parents": [
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/GO_0003906",
            "types": [
                "Entity",
                "Class"
            ],
            "short_form": "GO_0003906",
            "label": "NEIL1,NEIL2 incises DNA strand 5' to the AP site"
        },
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/GO_0016835",
            "types": [
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            ],
            "short_form": "GO_0016835",
            "label": "carbon-oxygen lyase activity"
        }
    ],
    "relationships": [],
    "xrefs": [],
    "anatomy_channel_image": [],
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        },
        {
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        },
        {
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                "label": "AP site-DNA 5'-phosphomonoester-lyase activity",
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        },
        {
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