CAAX-protein geranylgeranyltransferase activity [GO_0004662]
Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.
Note
This page displays the raw VFB json record for this term. Please use the link below to open the term inside the Virtual Fly Brain viewerOpen CAAX-protein geranylgeranyltransferase activity in VFB
VFB Term Json
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"label": "CAAX-protein geranylgeranyltransferase activity"
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"description": [
"Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families."
],
"comment": []
},
"query": "Get JSON for Class",
"version": "44725ae",
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],
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"anatomy_channel_image": [],
"pub_syn": [
{
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{
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{
"synonym": {
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{
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},
{
"synonym": {
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"label": "type I protein geranyl-geranyltransferase activity",
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}
],
"def_pubs": []
}
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