7-methylguanosine RNA capping [GO_0009452]
The sequence of enzymatic reactions by which the RNA 5’ cap structure, an inverted 7-methylguanosine linked via a 5’-5’ triphosphate bridge (m7G(5’)ppp(5’)X) to the first transcribed residue, is added to a nascent transcript. Additional methylation can occur on the ribose sugars of the first and second nucleotides adjacent to the m7G nRNA cap. These methylations are often referred to as N6,2’-O-dimethyladenosine (m6,2A) and N6,2’-O-dimethylguanosine (m6,2G), respectively.
7-methylguanosine RNA capping
ID: GO_0009452
Class
The sequence of enzymatic reactions by which the RNA 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. Additional methylation can occur on the ribose sugars of the first and second nucleotides adjacent to the m7G nRNA cap. These methylations are often referred to as N6,2'-O-dimethyladenosine (m6,2A) and N6,2'-O-dimethylguanosine (m6,2G), respectively.
Open in VFB 3D Browser →Classification
Alternative Names
| Synonym | Scope | Reference |
|---|---|---|
| RNA capping | broad synonym | mah |
| m(7)G RNA capping | exact synonym | mah |
References
Feedback
Was this page helpful?
Glad to hear it! Please tell us how we can improve.
Sorry to hear that. Please tell us how we can improve.