Who we are
Virtual Fly Brain members and their contribution:
Ontology editing, FlyBase support and data annotation:
Department of Genetics, University of Cambridge
Cahir O'Kane (current project PI)
Former contributors: Michael Ashburner (original PI and grant holder), Simon Reeve (2009 - 2011), Nicole Staudt (2015-2016)
This work was previously supported by a research award from the BBSRC to Douglas Armstrong and Michael Ashburner.
Details of this grant at Cambridge and
A UK e-Science Theme award to Douglas Armstrong helped us establish the project.
Marta Costa was also supported by a Isaac Newton Trust grant (October 2012 to September 2013).
The IIP3D server, Woolz software and client-side tools* are developed by:
MRC Human Genetics Unit (MRC HGU): Richard Baldock, Nick Burton, Bill Hill, Zsolt Husz
(*) An on-going development of the client-side tools is done in collaboration between the MRC HGU and Edinburgh University
Visit the EMAGE gene expression database
to see other tools the MRC HGU have developed.
is collaboratively curated by VFB and FlyBase
. Phenotype data
is curated by FlyBase. Expression and phenotype data displayed on VFB is stored and maintained by FlyBase.
We would like to thank Arnim Jenett of HHMI Janelia Research Campus, and Kei Ito and Kazunori Shinomiya of Tokyo University for the painted adult brain stack that we use on the 3D Brain Viewer.
We thank the group of A.S. Chiang (Brain Research Center, National Tsing Hua University, Taiwan) for making their FlyCircuit raw data available. We also thank Kei Ito (Tokyo University) and Tzumin Lee (HHMI Janelia Research Campus) for providing us with their neuroblast clone data.
We also thank the following researchers for their hard work in reviewing elements of VFB content:
Liria Masuda Nakagawa (Department of Genetics, University of Cambridge, Cambridge) for review of the larval olfactory system;
Orie Shafer (Molecular, Cellular and Developmental Biology, University of Michigan) for reviewing VFB pacemaker neuron terms and related content;
Jo Young (Institute for Adaptive and Neural Computation, University of Edinburgh) for review of the central complex;
Gregory Jefferis (MRC Laboratory of Molecular Biology, Cambridge) for review of the adult olfactory system.
Virtual Fly Brain uses open source software from a variety of sources:
- the OWL-API underpins handling of all ontology metadata and queries on VFB with help from the OWLtools and brain libraries;
- the super fast ontology queries that drive VFB would not be possible without the elk reasoner.
For more information on the technology behind the VFB website:
Milyaev, N., Osumi-Sutherland, D., Reeve, S., Burton, N., Baldock,
R. A. and Armstrong, J. D. (2012).
The Virtual Fly Brain browser and query interface. Bioinformatics 28, 411-5.
Husz ZL, Burton N, Hill B, Milyaev N, Baldock RA: Web tools for
large-scale 3D biological images and atlases. BMC Bioinformatics
For details on the anatomy ontology:
Osumi-Sutherland, D., Reeve, S., Mungall, C. J., Neuhaus, F.,
Ruttenberg, A., Jefferis, G. S. and Armstrong, J. D. (2012).
A strategy for building neuroanatomy ontologies. Bioinformatics 28, 1262-1269.
How to cite us
Please use the format below:
Milyaev, N., Osumi-Sutherland, D., Reeve, S., Burton, N., Baldock, R. A. and Armstrong, J. D. (2012). The Virtual Fly Brain browser and query interface. Bioinformatics 28, 411-5.
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Using our software or registered image data
The VFB software can be embedded in any third-party website where it can provide the same functionality as on the VFB website. This is because it was developed as part of an open source project and freely distributed under a GNU GPL2 license.
If you use our registered image stacks in any publication, please cite the original authors and the VFB project.